Alienation (noun)

1. The process of estranging someone or something, or the state of being estranged.
2. A feeling of being isolated, disconnected, or estranged from others or from society.

Origin:

Late middle english (originally as the adjective alienate): from latin alienatio(n-), from alienare 'to alienate'.

Examples:

1. Young people experiencing alienation from their peers often feel lonely and misunderstood.
2. The alienation of workers from the management can lead to low morale and decreased productivity.
3. Alienation from one's cultural heritage can result from living in a foreign country for an extended period.
4. The alienation of the protagonist from society is a common theme in dystopian literature.
5. Many people struggle with feelings of alienation in their personal and professional lives.