Irreversible (adjective)

Not able to be reversed or undone.

Origin:

Late 16th century, from in- + reversible.

Examples:

1. The process of melting the ice caps is irreversible.
2. The damage to his heart was irreversible and he needed a heart transplant.
3. Her decision to quit her job was irreversible, she couldn't change her mind.
4. The effects of climate change on the planet are irreversible if we don't act fast.
5. The law passed by the government is irreversible and cannot be amended.