Agony (noun)

1. Intense physical or mental suffering.
2. A state of great struggle or effort to achieve a goal.

Origin:

Late middle english: via old french from latin agonia, from greek agōnia, from agōn "contest".

Examples:

1. The patient was in agony from the pain.
2. She watched her son in agony as he struggled with addiction.
3. He was in agony as he tried to finish the marathon.
4. The team was in agony as they lost the final game.
5. The agony of the final decision was unbearable.