Amiss (adverb)

1. Not in a correct or suitable condition or position; wrong or out of place.
2. Not in good health or condition; unwell.

Origin:

Middle english (as a noun in the sense "harm"): from old english on mǣisse "in a wrong way," from mǣisse "wrong," of germanic origin; related to dutch maaien "to mow".

Examples:

1. It's clear that something is amiss in the company.
2. It was obvious that something was amiss with the car.
3. He knew something was amiss with his health.
4. It was apparent that something was amiss with the plan.
5. He could tell that something was amiss with her behavior.