Anguish (noun)

1. Extreme mental or physical pain.
2. A feeling of intense mental or emotional suffering.

Origin:

Middle english: from old french angoisse, from latin angustia "narrowing, distress", from angustus "narrow".

Examples:

1. She felt a great deal of anguish over the death of her child.
2. He was in anguish over the loss of his wife.
3. The patient's anguish was evident on his face.
4. Her parents were filled with anguish as they watched her suffer.
5. He was wracked with anguish and regret.