Annihilation (noun)

1. The act of reducing something to nothing or non-existence.
2. Complete destruction or obliteration of something.

Origin:

From the latin annihiliatio, from the verb annihilari, meaning "to reduce to nothing".

Examples:

1. The annihilation of the city by the enemy army left nothing but rubble.
2. The atomic bombs dropped on Hiroshima and Nagasaki resulted in the annihilation of both cities.
3. The company's reputation was destroyed by the scandal, resulting in its near-annihilation.
4. The virus led to the annihilation of the population in that area.
5. The new weapon had the power of instantaneous annihilation of the target.