Derangement (noun)

1. A state of mental or emotional disorder.
2. A disruption or disturbance of the normal functioning of the mind or emotions.

Origin:

From the verb derange, meaning "to put out of order" or "to disturb".

Examples:

1. The patient's symptoms were consistent with a severe derangement of the mind.
2. He was suffering from a derangement of the emotions that made it impossible for him to function normally.
3. The derangement of his mind was caused by years of drug abuse.
4. The derangement of his emotions was evident in his erratic behavior.
5. The derangement of his mental state caused him to have difficulty in carrying out daily tasks.