Disadvantage (noun)

1. A condition or circumstance that puts one in an inferior or less favorable position.
2. A disadvantageous condition or circumstance.
3. A lack of advantage or equality.
4. A disadvantageous state, condition, or situation.
5. An unfavorable condition, circumstance, or situation.

Origin:

Mid 16th century (in the sense "inferior position or condition"): from french désavantage, from des- (expressing negation) + avantage "advantage".

Examples:

1. The company's remote location is a disadvantage.
2. The small size of the company is a disadvantage.
3. The disadvantage of living in a small town is the lack of job opportunities.
4. The new policy has the disadvantage of increasing costs.
5. He is at a disadvantage because he doesn't speak the language.