Dysfunction (noun)

1. Abnormal or impaired functioning of an organ, part, structure, or system of the body resulting from disease, injury, alcohol or drug use, or other factors.
2. A failure to function normally or properly, especially in a social or psychological context.

Origin:

Mid 19th century: from dys- (expressing negation) + function.

Examples:

1. He was diagnosed with a dysfunction in his lower back.
2. The dysfunction of the company's management was the main reason for its failure.
3. The dysfunction in the government's ability to pass legislation was a major concern for citizens.
4. The dysfunction in the family dynamic was affecting all its members.
5. His alcoholism caused a dysfunction in his personal and professional life.