Embitter (verb)

1. To make bitter or resentful.
2. To make someone feel bitter or resentful.
3. To cause a situation to become bitter or resentful.

Origin:

Middle english embitteren, from old english embittrian, from en- + bittrian to make bitter, from bittere bitter.

Examples:

1. The betrayal embittered him towards his former friends.
2. The long legal battle embittered her toward the justice system.
3. The constant criticism embittered her towards her job.
4. The rejection embittered him and he never applied for a job again.
5. The loss embittered him and he never played the game again.