Fatigue (noun)

1. Physical or mental weariness resulting from exertion.
2. A state of weariness or exhaustion.

Origin:

From middle english, from old french fatigue, from fatiguer ("to tire"), from latin fatigare ("to tir.e")

Examples:

1. He was suffering from fatigue after a long day of work.
2. The soldiers were experiencing fatigue after days of marching.
3. The athlete was feeling fatigue in the last miles of the marathon.
4. The fatigue caused by the disease made it difficult for her to move.
5. The students were showing signs of fatigue after a long exam session.