Flyspeck (noun)

1. A tiny speck or stain, especially one made by a fly.
2. Something regarded as insignificant or worthless.

Origin:

Of uncertain origin, possibly from flea speck, as small spots on paper might resemble flea excrement.

Examples:

1. The walls were covered in a thick layer of grime and flyspecks.
2. The politician dismissed the accusations against him as mere flyspecks, and refused to acknowledge their importance.
3. The once-pristine painting was now marred by a multitude of flyspecks and cracks.
4. The author was famous for his meticulous attention to detail, and would spend hours removing flyspecks from his manuscripts.
5. The scientist's groundbreaking discovery was dismissed by his colleagues as a mere flyspeck, a minor contribution at best.