Frustrate (verb)

1. To prevent from achieving a goal or desired outcome.
2. To make (something) difficult or impossible to accomplish.
3. To thwart or oppose the plans or desires of.
4. To cause disappointment or discouragement in.
5. To make (someone) feel thwarted or impeded in their efforts.

Origin:

From middle english frustraten, from latin frustratus, past participle of frustrare ("to deceive, disappoint"), from frustum ("something broken, a fragment").

Examples:

1. His attempts to finish the project were frustrated by lack of resources.
2. The bad weather frustrated our plans to have a picnic.
3. She was frustrated by her inability to find a job.
4. He was frustrated by the lack of progress in the negotiations.
5. The constant interruptions frustrated her efforts to work.