Frustration (noun)

1. The feeling of being upset or annoyed as a result of being unable to change or achieve something.
2. The state of being frustrated.

Origin:

Late middle english (in the sense "obstruction"): from latin frustratio(n-), from frustrare "deceive".

Examples:

1. He felt frustration at not being able to find a job.
2. She felt frustration at not being able to finish the project.
3. The frustration of being stuck in traffic made him late for the meeting.
4. The frustration of losing the game was too much for him to bear.
5. The frustration of not being able to achieve his goals was weighing on him.