Heartache (noun)

1. Emotional pain or suffering caused by disappointment, grief, or unfulfilled desires.
2. A physical pain or discomfort in the chest that is often caused by emotional stress.

Origin:

The word heartache is a combination of the word heart and ache, both meaning emotional and physical pain.

Examples:

1. She was filled with heartache after her lover left her.
2. His heartache was so intense that it caused him to have chest pains.
3. The heartache of losing her child was unbearable.
4. He felt a heartache as he watched his love walk away.
5. The heartache of not getting the job was overwhelming.