Lifework (noun)

1. The work that one does during one's life, especially as a career or profession.
2. The total effort and output of an individual over the course of a lifetime, especially in a particular field.

Origin:

Compound of life + work.

Examples:

1. The scientist's lifework was devoted to researching the human genome.
2. The author's lifework was a collection of novels and short stories.
3. The artist's lifework was displayed in a retrospective exhibition.
4. The musician's lifework was celebrated in a concert.
5. The teacher's lifework was to educate young minds.