Misfortune (noun)

1. Bad luck or unfortunate events.
2. A state of having bad luck or unfortunate events.

Origin:

Late middle english: from old french mesfortune, from mes- (expressing bad or wrong) + fortune.

Examples:

1. The accident was a great misfortune to their fortune.
2. The fire was a misfortune to the company's fortune.
3. The company's fortunes took a turn for the worse after the scandal.
4. It was a misfortune to his fortune to lose his job.
5. The sudden death of his wife was a great misfortune to his fortune.