Profanation (noun)

1. The act of treating something sacred with disrespect or irreverence.
2. The act of desecration or corruption of something sacred.

Origin:

From latin profanatio, from profanare ("to treat (something sacred) as common or secular").

Examples:

1. The profanation of the holy temple was a sacrilege that could not be tolerated.
2. The tomb of the ancient king was a site of much profanation, with looters and grave robbers pillaging it for centuries.
3. He regarded the use of the Lord's name in vain as a profanation of something holy.
4. The profanation of the holy scripture was considered an act of great blasphemy.
5. The profanation of the sacred river was a great offense to the local community.