Puzzlement (noun)

1. A state of being confused or perplexed, unable to understand or explain something.
2. The feeling of being puzzled or bewildered.

Origin:

From the verb to puzzle, which comes from the latin word "puzzulus" meaning "bewildered".

Examples:

1. His answer caused much puzzlement among the scientists.
2. She looked at the instructions with puzzlement.
3. The audience was filled with puzzlement when the actor forgot his lines.
4. The children looked at the strange toy with puzzlement.
5. His behavior caused puzzlement among his friends.