Setback (noun)

1. A setback or hindrance to progress.
2. An unexpected problem or setback.
3. A loss of ground or progress.

Origin:

Late 19th century: from set back, as in 'put back in position', perhaps influenced by setback (adjective in the sense 'reversed in position').

Examples:

1. The project has suffered a major setback.
2. A financial setback made it difficult for her to pay her bills.
3. The company's growth has been slowed by several setbacks.
4. The recession has been a major setback for small businesses.
5. The delay in the project was a major setback for the team.