Unfamiliarity (noun)

The state or condition of being unfamiliar or not well known.

Origin:

From the prefix un- meaning not and the word familiarity.

Examples:

1. She was uncomfortable with the unfamiliarity of the city.
2. He felt a sense of unfamiliarity with the new job.
3. The unfamiliarity of the situation made him nervous.
4. The unfamiliarity of the culture was overwhelming.
5. The unfamiliarity of the language made communication difficult.