Whammy (noun)

A powerful or severe blow or setback; a severe disadvantage; a powerful effect; a hex or curse.

Origin:

Uncertain, possibly from the phrase "to put the whammy on" meaning to cast a spell or curse on someone.

Examples:

1. The company took a whammy when the new product launch failed.
2. The team was expecting to win, but the other team hit them with a whammy in the last seconds of the game.
3. The stock market took a whammy with the sudden drop in oil prices.
4. The news of her husband's infidelity was a whammy for her.
5. She put the whammy on him, and he started to feel unwell.