Wisecrack (noun)

1. A clever or witty remark or comment.
2. A sharp or clever retort or comment.

Origin:

A compound word, "wise" + "crack" meaning a clever remark, often made in a humorous or sarcastic way.

Examples:

1. He always had a wisecrack ready for any situation.
2. The comedian's wisecrack had the audience in stitches.
3. She was known for her sharp wisecracks and quick wit.
4. The wisecrack was a clever way of pointing out the irony.
5. He didn't appreciate the wisecrack and felt offended.