Woe (noun)

1. Great sorrow or distress.
2. An instance or cause of great sorrow or distress.
3. A condition of great trouble or unhappiness.

Origin:

Old english wā, of germanic origin; related to wail.

Examples:

1. The news of his death was a great woe to his family.
2. She was filled with woe when she heard the news.
3. The war brought woe to the country.
4. He was full of woe after the loss of his job.
5. The flood brought woe to the city.