Catastrophe (noun)

1. A sudden and severe disaster or event, typically one involving great loss or damage.
2. A very bad or unfortunate event or situation.

Origin:

The word "catastrophe" comes from the greek word "katastrophē" which means a turning upside down, it was first recorded in the english language in the 15th century.

Examples:

1. The hurricane was a catastrophe for the coastal community.
2. The accident was a catastrophe for the family.
3. The financial crisis was a catastrophe for the country.
4. The collapse of the bridge was a catastrophe.
5. The war was a catastrophe for the entire region.