Pain (noun)

1. An unpleasant physical sensation caused by injury or illness.
2. Emotional suffering, such as grief or distress.

Origin:

Old english pænan "punish, torment", of germanic origin; related to dutch pijn and german pein.

Examples:

1. I have a pain in my back.
2. The pain was so severe that she couldn't move.
3. The pain of losing her mother was unbearable.
4. He felt a sharp pain in his chest.
5. The pain of rejection is hard to overcome.