Twinge (noun)

1. A sudden sharp pain, typically in the muscles or nerves.
2. A sudden feeling of discomfort or anxiety.

Origin:

Middle english (denoting a sudden sharp pain): of unknown origin.

Examples:

1. He felt a twinge of pain in his back.
2. She felt a twinge of guilt for what she had said.
3. The twinge of pain was caused by a muscle spasm.
4. The twinge in his knee was a reminder of his old injury.
5. He experienced a twinge of sadness as he remembered his childhood.